D'OXYVA® (deoxyhemoglobin vasodilator) medical carbon dioxide
Circularity Healthcare, LLC
medical carbon dioxide pressurized mini gas cartridges
Read the Patient Information that comes with D'OXYVA before you start taking it and each time you get a refill. There may be new information. This leaflet does not replace talking with your doctor about your condition or treatment.
If you have any questions about D'OXYVA, ask your doctor or pharmacist.
What is D'OXYVA?
D'OXYVA is a prescription medicine for medical conditions and treatments that improves circulation, specifically microcirculation of your blood. It triggers vasodilation and vasoconstrictions in your vessels and oxygen offloading from your red blood cell's hemoglobin protein. Hemoglobin carries 98.5% of all oxygen in the body and carbon dioxide is responsible for catalyzing the offloading of oxygen via the so-called Bohr effect and it is also responsible for auto-regulation of local blood supply and blood pH. D'OXYVA is for adults and children over 10 whose circulation and oxygen levels are low and cannot improve enough with exercise and a low-fat diet alone.
D'OXYVA can lower the risk for chronic wounds, diabetes, rheumatoid arthritis, respiratory complications such as chronic obstructive pulmonary disease (COPD), heart attack, stroke, certain types of heart surgery, and chest, back and neuropathy pain in patients who have heart disease or risk factors for heart disease such as:
•age, smoking, high blood pressure, low HDL-C, heart disease in the family.
D'OXYVA can lower the risk for heart attack or stroke in patients with diabetes and risk factors such as:
•eye problems, kidney problems, smoking, or high blood pressure.
D'OXYVA starts to work in about 2 weeks.
What is Microcirculation?
The recognition of the importance of proper microcirculatory function has been growing rapidly in medical research in recent years. The fact is microcirculation in the capillaries is the most important system in the body. Capillaries facilitate exchange of nutrients, gases like oxygen and carbon dioxide, wastes, small proteins, and hormones between the blood and body cells. Capillaries web the entire body and every organ with an estimated average length of about 50,000 miles. The microcirculatory system helps the structure and function of connective tissue and helps clear congestion of lymph, skin and other vital tissues. It is the natural cleanser of the body as waste removal is one of the most important aspects of healthy microvascular function.
Who Should Not Take D'OXYVA?
Do not take D'OXYVA if you:
•are pregnant or think you may be pregnant, or are planning to become pregnant. D'OXYVA has never been reported or tested to cause harm to a pregnant woman or an unborn baby. U.S. FDA regulatory compliance requires that you are notified of any potential risks and if you get pregnant, stop taking D'OXYVA and call your doctor right away.
•are allergic to D'OXYVA or any of its ingredients. The active ingredient is purified carbon dioxide.
D'OXYVA has not been studied in children under 10 years of age.
Before You Start D'OXYVA
Tell your doctor if you:
•have muscle aches or weakness
•drink more than 2 glasses of alcohol daily
•have a thyroid problem
•have kidney problems
How Should I Take D'OXYVA?
•Take D'OXYVA exactly as prescribed by your doctor. Do not change your dose or stop D'OXYVA without talking to your doctor. Your doctor may do blood and noninvasive diagnostics tests to check your microcirculation (skin perfusion pressure), blood pressure, blood glucose, oxygen (SpO
2), and cholesterol levels during your treatment with D'OXYVA. Your dose of D'OXYVA may be changed based on these test results.
•Take D'OXYVA each day at any time of day at about the same time each day. D'OXYVA can be taken with or without food.
•If you miss a dose of D'OXYVA, take it as soon as you remember. If you miss taking D'OXYVA, wait and take the next dose at your regular time. You can take 2 doses of D'OXYVA at the same time or up to 4 doses per day. Clinical studies and users reported no additional benefits by taking more than 5 doses per day.
•D'OXYVA has never been reported to cause overdosing, however, call your doctor or Poison Control Center right away or go to the nearest emergency room if you experience lightheadedness or any problems breathing.
What Should I Avoid While Taking D'OXYVA?
•Talk to your doctor before you start any new medicines. This includes prescription and non-prescription medicines, vitamins, and herbal supplements. D'OXYVA and certain other medicines can interact causing positive side effects, however, on rare occasions it potentially may cause some negative side effects such as lightheadedness.
•Never inhale D'OXYVA or carbon dioxide directly from the pressurized mini cartridges.
What are the Possible Side Effects of D'OXYVA?
D'OXYVA has never been reported to cause any serious side effects. Mild side effects have happened only to a small number of people such as lightheadedness. Your doctor can monitor you for them. These side effects usually go away after a few applications or if D'OXYVA is stopped.
Call your doctor right away if you have:
•muscle problems like weakness, tenderness, or pain that happen without a good reason, especially if you also have a fever or feel more tired than usual. This may be an early sign of a rare muscle problem.
•muscle problems that do not go away even after your doctor has advised you to stop taking D'OXYVA. Your doctor may do further tests to diagnose the cause of your muscle problems.
•allergic reactions including swelling of the face, lips, tongue, and/or throat that may cause difficulty in breathing or swallowing which may require treatment right away.
•nausea and vomiting.
•passing brown or dark-colored urine.
•you feel more tired than usual
•your skin and whites of your eyes get yellow.
•allergic skin reactions.
In clinical studies, patients reported no adverse side effects while taking D'OXYVA.
Talk to your doctor or pharmacist if you have side effects that bother you or that will not go away.
These are not all the side effects of D'OXYVA. Ask your doctor or pharmacist for a complete list.
How do I store D'OXYVA?
•Store D'OXYVA at room temperature, 68 to 77°F (20 to 25°C).
•Do not keep medicine that is out of date or that you no longer need.
•Keep D'OXYVA and all medicines out of the reach of children. Be sure that if you throw medicine away, it is out of the reach of children.
General Information about D'OXYVA
Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. This leaflet summarizes the most important information about D'OXYVA. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about D'OXYVA that is written for health professionals. Or you can go to the D'OXYVA website at
What are the Ingredients in D'OXYVA?
Active Ingredient: 99.98% purified carbon dioxide
Inactive Ingredients: water
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